Mark Mattson: Building the Brain: Glutamate as Sculpture and Destroyer

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You’ve probably heard of Serotonin, or Dopamine. Those are the sexy neurotransmitters that get all the press. However, you have probably not heard of Glutamate. Which is a shame because it is probably the most important neurotransmitter in the brain, responsible in large part for its growth, and also its plasticity. Mark Mattson is a neuroscientist with a distinguished career as Director of the Laboratory of Neurosciences at the National Institute on Aging. While initially interested in developmental biology in animals, Mattson’s work in endocrinology led him to become to study the effect of hormones on the brain. Eventually he began to focus on the role of the Glutamate in neuroplasticity and Alzheimers disease. He realized how essential that neurotransmitter was for understanding the very formation of the brain, the growth of neurons, and the formation of axons and dendrites, as well as its key role in brain functions including learning and memory . I first got to know Mark when we co-organized a workshop on Pattern Processing in the Human Brain, where we invited well known neuroscientists as well as computer scientists and AI researchers to come together to discuss areas of joint interest. The idea was to explore key features that may underlie consciousness, and also to explore how to ensure how to avoid the error-prone brain functioning such as one finds in Schizophrenia as AI systems are developed. The public event associated with the workshop was entitled Creativity and Madness, and involved a dialogue between me and actor Johnny Depp. Most recently, Mark has written a fascinating book, entitled Sculptor and Destroyer, to describe and explain the importance of Glutamate in brain formation and functioning. We had a fascinating discussion about that, and also how he became interested in the brain after initially planning to become a veterinarian. I hope you find the discussion as enlightening as I did. As always, an ad-free video version of this podcast is also available to paid Critical Mass subscribers. Your subscriptions support the non-profit Origins Project Foundation, which produces the podcast. The audio version is available free on the Critical Mass site and on all podcast sites, and the video version will also be available on the Origins Project Youtube. Get full access to Critical Mass at lawrencekrauss.substack.com/subscribe