Weekly: Gene-editing to make superhumans; first bird flu death in the US; perfect pasta with physics

周刊:基因编辑创造超人; 美国出现首例禽流感死亡病例; 与物理学完美的面食

New Scientist Podcasts

科学

2025-01-10

28 分钟
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Episode 284 Creating disease-resistant humans may before too long be a reality thanks to advancements in CRISPR gene editing. It’s now possible to make dozens - if not hundreds - of edits to different genes at once. As the field progresses rapidly, a controversial paper published in Nature explores just how powerful this technology could be in protecting against diseases like Alzheimer’s and diabetes. But how safe is gene-editing? The paper has been criticised amid safety and ethical concerns, as well as the danger this could give rise to eugenics and designer babies. A person in Louisiana has died from bird flu, the first known death related to the H5N1 virus in the United States. Alarms are now being raised that bird flu could mutate and lead to another covid-like pandemic. The virus has evolved to infect many species of mammals, most recently dairy cows. But given we’ve been aware of this disease for decades and have stockpiled vaccines, what are the real concerns here? Hear from experts Meghan Davis and Andy Pekosz from Johns Hopkins University. Italian physicists have been working on an extremely important question related to…pasta. While working in Germany, Ivan Di Terlizzi and Giacomo Bartolucci became frustrated that they couldn’t perfectly recreate one of their favourite pasta meals - cacio e pepe. Thankfully, using their knowledge of phase behaviour, they figured out what was going on…in incredible detail. And bizarrely they suggest the finding may have implications for our understanding of the origins of life. Hosts Rowan Hooper and Penny Sarchet discuss with guests Michael Le Page and Grace Wade. To read more about these stories, visit https://www.newscientist.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices
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  • Hello and welcome to the latest Science insights from New Scientist.

  • I'm Penny Sashay, joined by my co host, Rowan Hooper.

  • Hello, hello, hello.

  • On the show this week, we're investigating the latest on the H5N1 bird flu and the prospects of it becoming a human pandemic or not.

  • And we're also hearing some really important news from Italian physicists on the most scientific way to make a classic pasta dish.

  • So, brilliant story.

  • Yeah, I'm really looking forward to this one, it has to be said.

  • But we're going to start with the latest on gene editing in humans.

  • And what we mean by that is the permanent changing of an embryo's genome such that the genetic changes would get passed on.

  • And it's illegal in most or in many parts of the world.

  • But famously, in 2018 in China, there was a geneticist called He Jiankui who used CRISPR gene editing to try to change the genes in human embryos.

  • And they were implanted into women and brought to term, and three little girls were born.

  • As far as we know, though, the editing didn't quite work as planned.

  • Yeah, that was a huge shock.

  • And he did go to prison for it.

  • He did.

  • He had got three years.

  • So the reason this is back in the news again, though, is there's a paper in Nature this week looking at this field because although hay only edited one gene in the embryo, it's now becoming possible, or it will be soon, to edit many, or maybe even dozens or more to make many edits to genes at once.

  • And that really raises the question of prospect of doing some really interesting different kinds of monkeying around with the genome.

  • Michael lepage is here to talk about this.